The Effect of BHA and BHT on Mixed Function Oxygenase of Liver Tissue

To evaluate the effect of BHA and BHT on liver tissue, BHA and BHT, 100mg and 200mg/kg B.W. respectively, were given to experimental animals for 4 months.

Microsomal cytochrome P-450, cytochrome b₅, cytochrome C reductase activity and lipid peroxidation of liver tissue of experimental animal were measured.

The results were as follow ;

1) Cytochrome P-450 increased significantly in experimental group given BHA but cytochrome b5 did not.

2) Cytochrome oxidnse activity increased moderately in BHA group but decreased in BHT group. From these finding, it can be assumed, that BHA and BHT has no great effect on human tissue.