An Experimental Study of the Effect of Cis-Dichlorodiammineplatinum(II) and Radiation on the Stomach of the Rats

Chemotherapeutic agents may alter the radiation response in the gastrointestinal epithelium by enhancing cell killing. Cis-dichlorodiammineplatinum(II)(Cis-DDP) has been known to interact with radiation, resulting in an apparent potentiation of radiation damage.

This experiment was designed to evaluate the enhancing potential of Cis-DDP for radiation effect in rat stomach.

Cis-DDP. 2.5mg/kg alone did not show significant changes in rat stomach. A single fraction of 6 and 8 Gy of radiation produced the slight submucosal edema only and 10 Gy of radiation produced the epithelial proliferation with atypical gland formation. There was no significant difference in findings of gastric mucosa according to the timing of Cis-DDP 2.5mg/kg administration before or after the radiation.