Histopathologic Study of non-Cancerous Lesion of the Prostate

Benign prostatic hyperplasia and prostatic carcinoma are the most frequent and important two lesions of the prostate. Sometimes we encounter the situations to solve the problems for the differential of cancerous lesions form various histopathologic changes in the microscopic examination of the prostate tissue obtained by curettage or resection in the patients of benign prostatic Hyperplasia. This study was undertaken to make an accurate histopathologic diagnosis of the prostate through the recognition of various microscopic changes similar to those of prostatic cancer and to understand the possibility of percancerous lesion in the dysplasia of the prostate.

Authors reviewed total 1,023 cases of prostatic tissre obtained during the last ten years from 1981 to 1990 at Ewha Womans University Tongdaemun Hospital, Wonju Christian Hospital and Yong-Dong Severance Hospital.

The results are as follows:

1) Among total 1,023 cases, 922 cases were benign prostatic hyperplasia and 101 cases were prostatic carcinoma.

2) Dominant age groups are seventies and eighties decades.

3) Nonspecific inflammation is found in almost cases of benign prostatic hyperplasia and the incidence of granulomatous inflammation was 2.7%, that of nonspecific granulomatous inflammation was 1.8% and that of tuberculosis was 1.0%.

4) The incidence of stromal nodule in benign prostatic hyperplasia was 30.5%, basal cell hyperplasia, 29.7%, sclerosing adenosis, 2.1% and dysplasia, 3.5%.

5) Among total 983 cases of prostate, 54 cases(5.5%) were dysplasea. The incidence of dysplasia in benign prostatic hyperplasia was 3.9% and that in prostatic carcinoma was 29.5%. The incidence of grade III dyplasea was 0.3% in benign prostatic hyperplasia and 13.1% in prostatic carcinoma. Therefore, of presence and occurance of associated carcinoma in the grade III dysplasia is highly present.