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The Ewha Medical Journal
Ewha Womans University School of Medicine

Ewha Med J 1987; 10(4):215-221

pISSN: 1598-7450

DOI: https://doi.org/10.12771/emj.1987.10.4.215

Original Article

Effects of CaCO3 Supplements on Serum Calcium and Phosuhorus in Patients on Hemodialysis Treatment

Joon Huh, Jung Hyun Chang, Yung Ho Cho, Kyun Il Yoon
Corresponding author: Kyun Il Yoon. Department of Internal Medicine, College of Medicine, Ewha Womans University, Korea.

Copyright ⓒ 1987. Ewha Womans University School of Medicine. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Published Online: Jul 24, 2015

Abstract

Phosphate binders that contain aluminum are usually prescribed to treat hyperphosphatemia in patients with chronic renal failure, but an accumulation of aluminum can lead to osteomalacia, encephalopathy and anemia. To evaluate the effect of CaCo3 on serum calcium and phosphorus as a alternative phosphate binder, we studied 13 patients on regular hemodialysis treatment. In basal period, some patients were administered Al(OH)3 and CaCO3, others only the former or the latter and others nothing. Al(OH)3 was stopped in all patients and CaCO3 was started or increased in all patients. A better control of sCa, sPi and sCa-Pi product was observed during only Ca supplementation, despite Al(OH)3 discontinuation. Some patients developed a mild hypercalcemia and hypophosphatemia, especially in those who had a normal predialytic sPi. Therfore considering the dialysate Ca concentration according to individual need and the adjustment of amount of CaC3 to avoid these risks can be recommanded with the dual objective of keeping a positive Ca balance and correcting hyperphosphatemia.