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The Ewha Medical Journal
Ewha Womans University School of Medicine

Ewha Med J 1988; 11(4):207-214

pISSN: 1598-7450

DOI: https://doi.org/10.12771/emj.1988.11.4.207

Original Article

Autoradiographic Study on the Distribution of Serotonin-2 Receptors in the Rat Brain

Hee Lai Lee
Corresponding author: Hee Lai Lee. Department of Anatomy, College of Medicine, Ewha Womans University, Seoul, Korea.

Copyright ⓒ 1988. Ewha Womans University School of Medicine. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Published Online: Jul 24, 2015

Abstract

The distribution of serotonin-2 receptors in the rat brain was studied by light microscopic autoradiography, using [3H]ketanserin as a ligand. The serotonin-2 receptor densities were quantified by an actual count of labeled silver grains from the tissue preparations. A heterogeneous distribution of serotonin-2 receptor densities was found in the rat brain. High concentrations of serotonin-2 receptors were localized over the superior colliculus, neostriatum, amygdaloid complex and mammillary body. Intermediate concentrations were found over the dentate gyrus and visual cortex(area 17). Low densities were found over the substantia nigra and olfactory tubercie. The observations made in this study indicate that the anatomical distribution of serotonin-2 receptor is in accord with the distribution of serotoninergic innervation and the densities of serotonin-2 preceptor are differences in brain area of rat.