Your browser does not support the NLM PubReader view.

Go to this page to see a list of supporting browsers.
The Ewha Medical Journal
Ewha Womans University School of Medicine

Ewha Med J 1988; 11(4):225-235

pISSN: 1598-7450

DOI: https://doi.org/10.12771/emj.1988.11.4.225

Original Article

Turning Behavior and Substantia Nigra Structure After Unilateral Lesion and of the Rat Neostriatum

Young Sook Pae
Corresponding author: Young Sook Pae. Department of Pharmacology, College of Medicine, Ewha Womans University, Seoul, Korea.

Copyright ⓒ 1988. Ewha Womans University School of Medicine. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Published Online: Jul 24, 2015

Abstract

After unilateral lesion of the rat neostriatum, we have been studied the relation between the behavioral chages of the rat and structural chages of the substantia nigra. We could find that a great number of axon terminals with pleomorphic vesicles in the ipsilateral substantia nigra were degenerated after one site lesion of neostriatum. while the structure of contralateral site was entirely intact. Also, we have been investigated that the contralateral asymmetry of posture and turning bebavior of the rat with lesion in the neostriatum. By the above results, it can be concluded that the axon terminal with pleomorphic vesicles in the substantia nigra ending of strio-nigral fibers and the degeneration of these ending is a cause to bring the contralateral postural asymmetry and/or circle behavior.