A Case if Wilson's Disease

Ho Kyung Kang, Sung Sook Park, Soon Ok Kim, Woo Hyung Lee

Corresponding author: Woo Hyung Lee. Department of Internal Medicine, College of Medicine, Ewha Womans University, Seoul, Korea.

Copyright ⓒ 1988. Ewha Womans University School of Medicine. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Published Online: Jul 24, 2015

Abstract

Wilson's disease is an autosomal recessive abnormality in the hepatic excretion of copper that results in toxic accumulation of the metal in liver, brain, and the other organs. Wilson's disease associated with brain lesion was found in 25-year-old woman who had dysarthria, wing-beating tremor, and Kayser-Fleisher ring. Laboratory data revealed hypoceruloplasminemia, hypercuprinuria, hypocupronemia and increased copper deposition in the liver biopsy specimen. The brain CT showed mild cortical atropy and bilateral low attenuation in lentiform nucleus.