Renal Fuction in Premature with Respiratory Distress Syndrome: The Effect of Perinatal Asphyxia

We studied the postnatal development of the renal function and the incidence of the renal dysfunction in premature with reapiratory distress syndrome, admitted to NICU, E.W.U.H. from March, 1986 to August 1989.

The results were as follows.

1) Renal function in Group I, RDS premature without perinatal asphyxia, was not different from the control values.

2) Renal function in Group II, RDS premature with perinatal asphyxia was different from the control values. Serum creatinine concentration was 1.05mg% at postnatal age 3 day and decreased to 0.88mg% at P.A 7 day. But both values were significantly higher than control values(P<0.05)

Creatinine clearance, 10.8ml/min/1.73m at P.A. 3 day which was significantly lower than control, but increased to 17.4ml/min/1.73m at P.A. 7 day which was not different from control value. Urine Na excretion and FENa were 5.2lmEg/kg/d and 3.81% at P.A. 3 day and decreaed to 3.42mEg/kg/d and 1.86% at P.A. 7 day. But both values were significantly higher than control values.(P<0.05) The incidence of proteinuria, oliguria and azotemia were significantly higher than control.(P<0.05)

In conclusion, RDS per se did not compromise the renal function. But associated perinatal asphyxia delayed the postnatal development of the glomerular function and the tubular reabsorptive capacity which seemed to be transient.