Effects of Acetate & Bicarbonate Dialysate In Patients with Maintenance Hemodialysis

Young Ho Cho, Sung Bae Kim, Hye Won Lee, Yang Hee Lim, Kyun Il Yoon

Copyright ⓒ 1989. Ewha Womans University School of Medicine. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Published Online: Jul 24, 2015

Abstract

The utilization of acetate & bicarbonate dialysate and their effects on acid-base balance, blood pressure, pulse rate, serum cholesterol, triglyceride, HDL and free fatty acid were investigated during regular hemodialysis.

Eight patients with chronic renal failure were studied during two successive dialysis treatments for which either acetate or bicarbonate were used as a buffer anion in the dialysate.

The result obtained as follows :

1) There was no significant difference in arterial pH between acetate and bicarbonate hemodialysis patients.

2) Arterial HCO₃ was higher significantly in patients with bicarbonate hemodialysis than acetate hemodialysis from 60 to 240 minutes (p<0.01)

3) Arterial pCO₂ fell significantly from 34.0 mmHg to 31.7 mmHg during acetate hemodialysis patient (p<0.01)

4) Heart rate rose signifificantly from 69 b.p.m to 82 b.p.m. during acetate hemodialysis(p<0.01).

5) Serum fatty acid increased significantly during acetate and bicarbonate hemodialysis, but no difference between two groups.

6) There were no significant changes in systolic and diastolic blood pressure in two groups during hemodialysis.

7) There were no significant changes in serum cholesterol, triglyceride and HDL in two groups during hemodialysis.