Conservative Treatment of Ectopic Pregnancy with Methotrexate

Chong Il Kim

Copyright ⓒ 1991. Ewha Womans University School of Medicine. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Published Online: Jul 24, 2015

Abstract

Seventeen subjects with ectopic pregnancies were treated with five doses of intramuscular methotrexate(25mg) injection follow by five doses of Citovorum factor(3mg).

Seventeen subjects were 11 tubal. 4 cornual. and 2 cervical pregnancies.

The diagnosis was established in tubal and cornual pregnancies by laparoscopy following sonography and radioimmunoassay for serum β-subunit of human chorionic gonadotropin. Subjects were followed with every 3 days quantitative serum HCG and sonography.

Fifteen of the seveteen subjects experienced resolution of the ectopic mass and was subjected underwent one cornual resection and one salpingectomy.

The duration of disappearance of β-HCG to normal after treatment were 2~6 weeks.

The most of all subjects were 2~3 weeks(60%). This experience suggests the methotrexate may be an effective alternative for the treatment of early ectopic pregnancy and useful the treatment of cornual. cervical pregnancy.