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The Ewha Medical Journal
Ewha Womans University School of Medicine

Ewha Med J 1992; 15(3):253-260

pISSN: 1598-7450

DOI: https://doi.org/10.12771/emj.1992.15.3.253

Original Article

Experimental Study of the Effect of Contrast Agent on the Fallopian Tubes of Rabbits

Eun Chul Chung

Copyright ⓒ 1992. Ewha Womans University School of Medicine. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Published Online: Jul 24, 2015

Abstract

Hysterosalpingography is a valuable diagnostic tool in the investigation of the uterine and tubal factors of female infertility.

Author evaluated the effect of different iodinated contrast agents on the fallopian tube and adnexal tissue in 16 rabbits. Lipiodol, an oil-soluble agent, was used for 4 rabbits. The following water soluble contrast agents were used for 12 rabbits: iothalamate meglumine 60%, diatrizoate sodium, and iopromide. The agents injected through the catheter placed in the fallopian tube. Fallopian tubes and peritoneal cavities were evaluated histologically. Iothalamate meglumine and diatrizoate sodium contrast agents, were associated with mild to moderate Inflammation and edema. Iopromide. which has low osmolarity, produced mild inflammation compared to ionic contrast agents. Use of oil-soluble contrast medium resulted in fibrous adhesion, moderate to marked inflammation and tissue edema in fallopian tubes andperiovarian tissues.

The safety of oil-soluble contrast agents for hysterosalpingogrpahy is questioned. Therefore, contrast agents with low osmolarity are suitable for use in hysterosalpingography.

Keywords: Hysterosalpingography; Rabbit