Primary Signet Ring Cell Adenocarcinoma of the Bladder: Report of Two Cases

Seok Heun Jang, Jun Young Jeon, Bong Suck Shim, Sung Won Kwon

Copyright ⓒ 1993. Ewha Womans University School of Medicine. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Published Online: Jul 24, 2015

Abstract

Primary signet ring cell adenocarcinoma of the bladder accounts for less than 1 per centof all primary bladder neoplasm. 19 cases have been reported in the literature.

This tumor is insidious because of its subepithelial infiltrative nature, which makes diagnosis possible only late in the course of the disease.

Survival is poor ; greater 50 per cent of the patients are dead within a year after diagnosis.Radical surgery offers the only hope of palliation ; irradiation and chemotherapy have notbeen effective.

We are reporting two cases of primary signet ring cell adenocarcinoma of the bladder treatedwith radical cystectomy with pathological findings and review of the literature.