Clinical and Histologic Study of Sclerotherapy in the Rabbit Ear Vein Model : Basic Research for Treatment of Varicose and Telangiectatic Vein

Sclerotherapy has become a popular method for obliterating both varicose veins and telangiectases. Through the animal model of sclerotherapy, we would understand its mechanism as a basis of clinical application. Clinical and histologic changes were observed periodically after injecting the hypertonic saline into the dorsal marginal rabbit ear vein, and the results were as follows.

There was no color and diameter changes in the vein after the normal saline injection as a control. Clinical changes after injection of sclerosant were that the color of vein changed to blue or dark blue at the early period, and it eas faded out one month later. Histologic examination after injection of sclerocant showed the intravascular thrombosis, cutaneous necrosis, vascular proliferations, and fibrosis at the early period, and large vein was disappeared and replaced by several telangiectasis and matured fibrosis one month later.

We could predict the outcome clinically and histologically, and the complication like cutanceous necrosis should be warned during the clinical application.