Striatal Network Model in Parkinson Disease: Preliminary Study

Kyoung Gyu Choi, Kee Duk Park

Copyright ⓒ 1996. Ewha Womans University School of Medicine. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Published Online: Jul 24, 2015

Abstract

Objective

To construct the neural network model in the striatum that can explain the clin-ical effect of Parkinson disease.

Methods

We use an approach to studying the function of neural systems that is based on the use of a class of computer models known as parallel distributed processors(PDPs).And the focus of this study is the nigrostriatal dopaminergic effects on the corticostriatal fibers and the striatal medium spiny neurons.

Results

A model that explains hypokinesia in Parkinson disease is presented for the opation of the striatum.

Conclusions

In order to study the brain funcion and mechanism of physiopathology, te-stable theories that consider brain as a whole system are needed. We think neural network model with PDPs would be an important field in neuroscience in near future.

Keywords: Neural network; Parallel distributed processors; Parkinson disease