The Effect of Allopurinol and Veraoamil on the Peritoneal Adhesion Induced by Ligation of the Local Peritoneum in the Rats

The postoperative peritoneal adhesions are associated with numerous complications, including small bowel obstruction, difficult and dangerous reoperations, and infertility. However the adhesion formation is inevitable phenomenon after abdominal surgery. In this study, a reproducible, quantitative rat model was developed that used uniform ischemic injury on the parietal peritoneum of the area over the right lateral thoracoepigastric vessles. The resulting adhesions and the inflammatory reaction of the insulted area were subsequently scored. And then two potential antiadhesive agents, allopurinol and verapamil, were tested and compared.

The result suggest that verapamil appeared to be very effective in reducing adhesion formation but not with allopurinol. However, there was not significant relation to the severity of peritoneal adhesion and inflammatory reaction.