Positive Rate of CLO Test according to the Grade of Gastritis Which was Asessed by Histopathologic Examination

Doe Young Kim

Copyright ⓒ 1999. Ewha Womans University School of Medicine. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Published Online: Dec 31, 1999

Abstract

Objectives

Sydney system in the classfication of histologic gastritis recommends the grading of Helicobacter(H.) pylori density, activity and chronic inflammation. CLO test is a rapid urease test to diagnose H. pylori infection. The relation between the grading of gastritis and the positivity of the CLO test has not been well studied. Accordingly, this study was performed to investigate the positive rate of the CLO test according to the grade of gastritis.

Methods

One hundred consecutive endoscopy patients had two antral biopsies for CLO test and histopathologic examination. H. pylori density, activity and inflammation were each graded into 0, 1, 2, and 3.

Results

1) CLO test was positive in 52 among 100 cases(52%) and among the CLO test positive cases, forty five(86.5%) became positive within 1 hour.

2) The positive rate of the CLO test increased according to the grade of H. pylori density, mucosal activity and chronic inflammation.

3) The group(n=45) who turned positive within 1 hour showed higher grade of H. pylori density than the group(n=7) who turned positive from 1 to 24 hour.

Conclusion

It was thought that the grade of histologic gastritis reflected the positive rate of the CLO test and reaction time to a positive CLO test is related to H. pylori density.

Keywords: Gastritis; Grade; CLO test