The Ewha Medical Journal
Ewha Womans University School of Medicine
Original Article
Analysis of EBV in Extranodal NK/T Cell Lymphoma
Min-Sun Cho, So-Youn Woo*
Published Online: Sep 30, 2004
Abstract
Objectives
Epstein-Barr virus(EBV) is associated with development of various types of lymphoma, especially NK/T cell lymphoma. Recently, its subtypes and LMP-1, major oncoprotein of EBV, have been studied. We investigated the frequency of EBV, its subtypes, and LMP-1 status on the cases diagnosed at Ewha university hospital between 1993 and 2002.
Material and Methods
Sixteen cases of NK/T cell lymphomas were studied. In situ hybridization for EBER-1 mRNA and PCR for EBV subtypes and 30 base pair deletion of LMP-1 were done.
Keywords: Epstein-Barr virus; Genotype; LMP-1; NK/T cell Lymphoma; Extranodal