The Effect of Tranquilizer on 3-Hydroxy-3-Methylglutaryl-CoA Reductase of Liver and Brain Tissue of Rats

The incidence of mental illness in the modern society has been increasing and the use of the tranquilizer for the treatment of these illnesses has been increasing also. The side effects of the tranquilizer are reportedly, minimal and the long term use of the medicine is widely practised in this field. But the question of its effect on cardiovascular system has been discussed previously and the level of cholesterol and triglyceride was found to increase in patients who have been on the tranquilizer for a long period of time. The current study was undertaken to find out the effect of tranquilizer(chlorpromazine, thioridazine, perphenazine, haloperidol, and pimozide) given to the animals for 4 weeks. And the results are summarized as follow: 1) In the animal group given chlorpromazine, thioridazine, and perphenazine, the level of total serum cholesterol was increased and the activity of microsomal HMG-Co A reductase was also increased. However, in the group given haloperidol and pimozide, there was no increase of cholesterol level or activity of microsomal HMG-Co A reductase. 2) The correlation of serum total cholesterol level and the activity of HMG-Co A reductase in the liver and brain was significant. From the Above results, it could be concluded that the effect of the long term use of tranquilizer on the cadiovascular systerm should be reevaluated.