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The Ewha Medical Journal
Ewha Womans University School of Medicine

Ewha Med J 1982; 5(3):109-116

pISSN: 1598-7450

DOI: https://doi.org/10.12771/emj.1982.5.3.109

Original Article

The Effects of Vitamin Antioxidants on Lipid Peroxidation in Rat Liver Microsomes

Yoon Ae Ham, Young Sook Hong, Nak Eung Sung
Corresponding author: Nak-Eung Sung. Department of Biochemistry College of Medicine Ewha Womans University, Korea.

Copyright ⓒ 1982. Ewha Womans University School of Medicine. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Published Online: Jul 24, 2015

Abstract

We observed the effect of the administration of vitamin A,C and E with β-naphthoflavone and piperonyl butoxide on cytochrome P-450 level and lipid peroxidation in rats liver. The level of hepatic cytochrome P-450 decreased after vitamin A,C and E was administration. In contrast, β-naphthoflavone, when administered with vitamin A,C and E, the increase of cytochrome P-450 was prevented. Lipid peroxidation was decreased after vitamin A, C, and E was administered. Moreover when β-naphthoflavone was administered together with vitamin A, C and E lipid peroxidation was not increased. When piperonyl butoxide was administered together with vitamin A,C and E, both cytochrome P-450 and lipid peroxidation were decreased. These results indicate that vitamin antioxidants can prevent lipid peroxidation by a cytochrome P-450 dependent terminal oxidase system in rat liver microsomes.