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The Ewha Medical Journal
Ewha Womans University School of Medicine

Ewha Med J 1983; 6(2):57-64

pISSN: 1598-7450

DOI: https://doi.org/10.12771/emj.1983.6.2.57

Original Article

The Effects of Vitamin Antioxidants on Lipid Peroxidation in Carbon Tetrachloride, Phenobarbital and Artemisia Messes - Schmidiana Var Viridis - Preteated Rats Liver Microsomes

Eun Kyoung Han, Young Sook Hong, Hak Eung Sung, Young Sook Pae
Corresponding author: Young-Sook Pae. Department of Pharmacology, College of Medicine, Ewha Womans University, Korea.

Copyright ⓒ 1983. Ewha Womans University School of Medicine. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Published Online: Jul 24, 2015

Abstract

After rats were treated with CC14, phenobarbital and artemisia messes-schmiaiana var viridis(artemisia), hepatic microsomal cytochrome P-450, cytochrome b5 and lipid peroxidation were investigated. When vitamin A, C and E were added incubation medium in each group respectively, lipid peroxidation was observed. The results were as follows. 1) When administrated with CC14 in rats, the contents of total microsomal cytochrome P-450 and cytochrome b5 were decreased by 58% and 36%, respectively. And lipid peroxidation was decreased to by 6%. 2) When administrated with phenobarbital and artemisia. in rats respectively, the contents of total microsomal cytochrome P-450 and cytochrome b5 were increased by 25 to 135%. And lipid peroxidation was increased by 30 to 57%. 3) When administrated with CC14 and phenobarbital or artemisia. in rats, the contents of total microsomal cytochrome P-450 and cytochrome b5 were increased by 8 to 35%. And lipid peroxidation was increased by 4 to 14%. 4) When vitamin A, C and E incubated in each group in each group in vitro, lipid peroxidation were decreased by 3 to 87%. And th higher concentrations of vitamin A, C and E were, the more lipid peroxidation was decreased. These results indicate that vitamin antioxidants can prevent lipid peroxidation in CC14, phenobarbital, CC14 with phenobarital. artemisia. and CC14 with artemisia.-pretreated rat liver microsomes.