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The Ewha Medical Journal
Ewha Womans University School of Medicine

Ewha Med J 1984; 7(1):3-7

pISSN: 1598-7450

DOI: https://doi.org/10.12771/emj.1984.7.1.3

Original Article

The Effects of Vitamin A and E on Lipid Peroxidation in Ethanol Administered Rat Liver Microsomes

Young Sook Hong, Yoon Ae Ham, Nak Eung Sung
Corresponding author: Nak Eung Sung. Department of Biochemistry, College of Medicine, Ewha Womans University, Korea.

Copyright ⓒ 1984. Ewha Womans University School of Medicine. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Published Online: Jul 24, 2015

Abstract

Ethanol enhances the activity of microsomal enzyme system and lipid peroxidation. We observed the effect of chronic ethanol administration on cytochrome P-450 level and lipid peroxidation in rat liver microsome. The results were as follows : 1) When rats were administered with ethanol, the level of microsomal cytochrome P-450 was decreased and lipid peroxidation did not change significantly. 2) When vitamin A and E were added incubation medium in each group, lipid per-oxidation was decreased significantly.