Your browser does not support the NLM PubReader view.

Go to this page to see a list of supporting browsers.
The Ewha Medical Journal
Ewha Womans University School of Medicine

Ewha Med J 1985; 8(3):165-170

pISSN: 1598-7450

DOI: https://doi.org/10.12771/emj.1985.8.3.165

Original Article

Studies on the Hepatic Microsomal Mixed Function Oxidase System with Higenamine on the Rat

Young Sook Hong, Young Sook Pae*, Nak Eung Sung
Corresponding author: Nak-Eung Sung. Department of Pharmacology, College of Medicine, Ewha Womans University, Korea.

Copyright ⓒ 1985. Ewha Womans University School of Medicine. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Published Online: Jul 24, 2015

Abstract

The effect of intraperitonelly administered higenamine on the cytochrome P -450, b5, P-nitroanisole-O-demethylase and lipid peroxidation in the rat hepatic microsomes were determined. The following results were obtained ; 1) The intraperitonelly administered higenamine increased contents of rat hepatic microsomal cytochrome P-450 and b5. 2) The principal role of cytochrome P-450 in mixed function oxidase reactions includes hydroxylation of various drugs, fatty acids, steroids, pesticides and carcinogens. The increased cytochrome P-450 induced by higenamine decreased on the both AAF of N-hydorxylation and Ring-hydroxylation. 3) Activity of P-nitroanisole-O-demethylase in hepatic microsomes with higenamine was decreased accorting to incresed dosage of higenamine. 4) The formation of lipid peroxides was increased according to increased dosage of higenamine.