Your browser does not support the NLM PubReader view.

Go to this page to see a list of supporting browsers.
The Ewha Medical Journal
Ewha Womans University School of Medicine

Ewha Med J 1985; 8(1):49-55

pISSN: 1598-7450

DOI: https://doi.org/10.12771/emj.1985.8.1.49

Original Article

The Effect of Estradiol and Progesterone on the Concentration of Estradiol Receptor in Uterine Tissue During the Early Pregnancy of Rats

Sun Rye Kim, Kyung Za Ryu*, Wan Kyoo Cho**
Corresponding author: Wan Kyoo Cho. Department of Zoology, College of Natural Science, Seoul National University, Korea.

Copyright ⓒ 1985. Ewha Womans University School of Medicine. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Published Online: Jul 24, 2015

Abstract

The present study was undertaken to determine the effect of estrogen and progesterone on the concentration of estradiol receptor in uterine tissue at the early pregnant rats. The result obtained are as follows : 1) The uterus wet weights of ovariectomized rats were decreased, while the concentration of estradiol receptor(E2R) was increased, it seems to be well correlated with the low level of estrogen. 2) In the rats treated with estradiol, at 24 hours after treatment, the concentration of E2R was higher than control-vehicle treatment-groups. 3) In the rats treated with estrogen and progesterone, the concentration of E2R decreased, whereas estrogen primed rats treated with progesterone, the concentration of E2R increased relatively. It is, therefore, concluded that the concentration of cytosol E2R seems to be correlated with the peripheral estrogen and progesterone levels and then cytosol E2R transfers into nuclear estradiol receptor to stimulate mRNA transcroption for the development of uterine tissue.