Table 1. Classification of statins

	Simvastatin	Pitavastatin	Lovastatin	Fluvastatin	Rosuvastatin	Pravastatin	Atorvastatin
Type	Natural	Synthetic	Natural	Synthetic	Synthetic	Natural	Synthetic
Solubility	Lipophilic	Lipophilic	Lipophilic	Lipophilic	Hydrophilic	Hydrophilic	Lipophilic
BBB permeability	High	Low	High	Low	Low	Low	Low
Half-life (hours)	1−2	12	2	4.7	19	1−2	14

BBB, blood-brain barrier.