| Bourhis et al. [15] | Lymphoma | Case report | Multi-resistant CD30+ T-cell cutaneous lymphoma | 1 | Electrons (5.6 MeV, 166 Gy/s) | 15 Gy in a single fraction | - Follow-up of 5 months- Rapid, complete, and durable tumor response- Grade 1 epithelitis and edema- Intact epidermis and basal membrane- Limited increased vascularization |
| Gaide et al. [72] | Lymphoma | Case report | Multi-resistant CD30+ T-cell cutaneous lymphoma | 1 (2 sites) | Electrons (5.6 MeV, 166 Gy/s) | 15 Gy in a single fraction- Right elbow: 0.08 Gy/s- Left distal arm: 166 Gy/s | - Follow-up of 2 years- Rapid, complete, and durable tumor response- Grade 1 acute epithelitis at both treated sites- Mild late radiodermatitis at both treated sites |
| Mascia et al. [73] | Bone metastasis | ProspectiveSingle armFeasibility study | 1–3 symptomatic bone metastases in the extremities (except for the feet, hands, or wrists) | 10 (12 sites) | Protons (250 MeV, 51–61 Gy/s) | 8 Gy in a single fraction | - Median follow-up of 4.8 months (range, 2.3–13.0)- Average patient time on the treatment couch 18.9 minutes (range, 11–33)- No device-related treatment delays- Transient pain flares (2–9 days post-FLASH) in 4 of the 12 sites (33%)- Pain relief in 8 of the 12 sites (67%)- No pain in 6 of the 12 sites (50%)- No grade ≥3 FLASH-related toxicity |