Table 1. Integrated morphological-molecular classification of hepatocellular carcinoma

Classification system Proliferative class Non-proliferative class
Lee et al. [15] Cluster A Cluster B
Boyault et al. [16] G1, G2, G3 G4, G5, G6
Chiang et al. [17] Proliferation Interferon, Poly7, CTNNB1
Hoshida et al. [18] S1, S2 S3
TCGA Research Network [13] Immune high and intermediate Immune excluded
Sia et al. [19] iClust1, iClust3 iClust2
Clinical features Poor clinical outcome, high AFP, HBV, frequent vascular invasion Improved clinical outcome, low AFP, HCV, low vascular invasion
Histological features Poorly differentiated Well differentiated
Molecular alterations Chromosomal instability, TP53 mutations, FGF19 amplification Chromosomal stability, CTNNB1 mutations, TERT promoter mutations
AFP, alpha-fetoprotein.