Lee et al. [15] | Cluster A | Cluster B |
Boyault et al. [16] | G1, G2, G3 | G4, G5, G6 |
Chiang et al. [17] | Proliferation | Interferon, Poly7, CTNNB1 |
Hoshida et al. [18] | S1, S2 | S3 |
TCGA Research Network [13] | Immune high and intermediate | Immune excluded |
Sia et al. [19] | iClust1, iClust3 | iClust2 |
Clinical features | Poor clinical outcome, high AFP, HBV, frequent vascular invasion | Improved clinical outcome, low AFP, HCV, low vascular invasion |
Histological features | Poorly differentiated | Well differentiated |
Molecular alterations | Chromosomal instability, TP53 mutations, FGF19 amplification | Chromosomal stability, CTNNB1 mutations, TERT promoter mutations |