The Experimental Study on the Effect of Radiation and Cis-Dichlorodiammineplatinum(II) in Rat Skin

The interaction of Cis-dichlorodiammineplatinum(II)(Cis-DDP) with irradiation may be important in the clinical settings for which this drug is currently used.

Since the skin is a major tissue for the uptake of Cis-DDP and its uptake level persists for several days, experiments were designed to evaluate the potential of Cis-DDP for enhancing the damage or the irradiated skin in rats.

For experiments, 42 rats were used and radiation dose was 30Gy in single fraction and the dose of Cis-DDP was 2.5mg/kg. The results of these experiments suggest that a Cis-DDP dose of 2.5mg/kg produces no incrase skin damage when the drug was administered IP 30min before, or 15min after irradiation.