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The Ewha Medical Journal
Ewha Womans University School of Medicine

Ewha Med J 1990; 13(4):301-306

pISSN: 1598-7450

DOI: https://doi.org/10.12771/emj.1990.13.4.301

Original Article

The Experimental Study on the Effect of Radiation and Cis-Dichlorodiammineplatinum(II) in Rat Skin

Kyung Ja Lee

Copyright ⓒ 1990. Ewha Womans University School of Medicine. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Published Online: Jul 24, 2015

Abstract

The interaction of Cis-dichlorodiammineplatinum(II)(Cis-DDP) with irradiation may be important in the clinical settings for which this drug is currently used.

Since the skin is a major tissue for the uptake of Cis-DDP and its uptake level persists for several days, experiments were designed to evaluate the potential of Cis-DDP for enhancing the damage or the irradiated skin in rats.

For experiments, 42 rats were used and radiation dose was 30Gy in single fraction and the dose of Cis-DDP was 2.5mg/kg. The results of these experiments suggest that a Cis-DDP dose of 2.5mg/kg produces no incrase skin damage when the drug was administered IP 30min before, or 15min after irradiation.