Your browser does not support the NLM PubReader view.

Go to this page to see a list of supporting browsers.
The Ewha Medical Journal
Ewha Womans University School of Medicine

Ewha Med J 1992; 15(4):413-417

pISSN: 1598-7450

DOI: https://doi.org/10.12771/emj.1992.15.4.413

Original Article

The Effect of Halothane, Enflurane and Isoflurans on Hepatic Function in Acute Hypoxic Rats

Guie Yong Lee

Copyright ⓒ 1992. Ewha Womans University School of Medicine. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Published Online: Jul 24, 2015

Abstract

The effects of halothane, enflurane and isoflurane on hepatic function in 50 Sprague-Dawley rats in the presence of acute mild hypoxic(oxygen 14%) condition were compared. Anesthetics were administered in 1 MAC halothane (1%), enflurane(2.2%), isoflurane(1.4%) with 40% oxygen for 1 hour, 24 hours later serum alaninie aminotransferase(ALT) and asparate aminotransferase(AST) measured. There were no statistically significant differences of ALT among study groups. There were significant differences of AST between hypoxic group and halothane, enflurane and isoflurane groups.

This study shows that admintistration of 40% oxygen with 1 MAC halothane, enflurane and isoflurane in acute mild hypoxic condition was not harmful on hepatic function.