The Effect of Halothane, Enflurane and Isoflurans on Hepatic Function in Acute Hypoxic Rats

The effects of halothane, enflurane and isoflurane on hepatic function in 50 Sprague-Dawley rats in the presence of acute mild hypoxic(oxygen 14%) condition were compared. Anesthetics were administered in 1 MAC halothane (1%), enflurane(2.2%), isoflurane(1.4%) with 40% oxygen for 1 hour, 24 hours later serum alaninie aminotransferase(ALT) and asparate aminotransferase(AST) measured. There were no statistically significant differences of ALT among study groups. There were significant differences of AST between hypoxic group and halothane, enflurane and isoflurane groups.

This study shows that admintistration of 40% oxygen with 1 MAC halothane, enflurane and isoflurane in acute mild hypoxic condition was not harmful on hepatic function.