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The Ewha Medical Journal
Ewha Womans University School of Medicine

Ewha Med J 1983; 6(1):17-22

pISSN: 1598-7450

DOI: https://doi.org/10.12771/emj.1983.6.1.17

Original Article

Studies on the Effect of CCl4, Phenobarbital and Artemisia Messes-schmidiana val viridis on Biliary Excretion in Rat

Young Sook Pae
Corresponding author: Young Sook Pae. Department of Medicine, College of Medicine, Ewha Womans University, Korea.

Copyright ⓒ 1983. Ewha Womans University School of Medicine. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Published Online: Jul 24, 2015

Abstract

After animals were treatd with CCl4, histological changes were shown in the endoplasmic reticulum, and also microsomal activity was decreased and hepatic necrosis, lipid peroxidation in the liver were repoted. Repeated administration of phenobarbital results in the induction of enzyme that metabolize a number of drugs and, Roberts and Plaa reported that bilirubin output was increased significantly after administration of phenobarbital in rats. Artemisia. was used as folk medicine for the treatment of hyperbilirubinemia. Kiku Tanni(1968) claimed that administration of Artemisia. in patient with acute hepatitis, significantly lowered the bilirubin index, S.G.O.T. and S.G.P.T. The purpose of the this report was to study the effect of CCl4, phenobarbital. Artemisia on biliary excretion. The results obtained are summarized as follows. 1) Volume of the bile juice was decreased in CCl4 group but increased in phenobarbital and Artemisia. group. 2) Biliary output was slightly decreased in CCl4 group but increased in phenobarbital group. 3) Cholate output was decreased in CCl4 group, but phenobarbital and Artemisia group was shown sighificant increase. 4) Cholesterol output was decreased in CCL4 group, but increased in phenobarbital group. By the above results, it is felt that after treated with phenobarbital and artemisis following liver damage with CCl4, detoxication process was shown and the liver damage were protected.