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The Ewha Medical Journal
Ewha Womans University School of Medicine

Ewha Med J 1986; 9(1):49-54

pISSN: 1598-7450

DOI: https://doi.org/10.12771/emj.1986.9.1.49

Original Article

A Study of Glomerulonephropathy Induced by Adriamycin in Rats

Ok Kyung Kim
Corresponding author: Ok Kyung Kim. Department of Pathology, College of Medicine, Ewha Womans University, Korea.

Copyright ⓒ 1986. Ewha Womans University School of Medicine. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Published Online: Jul 24, 2015

Abstract

Adriamycin is one of the most effective antitumor for carcinoma and sarcoma of variable internal organ. ADR induced cardiotoxicity has been reported as an serious complication. However recentely ADR induced nephrotoxicity has been documented in a variety of animal species. The present study was aimed to analyse the light and electron microscopic findings of renal glomeruli and tubules of rats treated by ADR. The results of the experiment are as follows: 1) The major histopathologic findings of Adriamycin induced glomerulonephropathy in rats are mesangeal thickeness and vacuolization of epithelial cell. 2) The major electron microscopic finding of ADR glomerulonephropathy in rats are focal or diffuse foot process fusion and vacuolization of epithelial microvilli. 3) Those light and electron microscopic glomerulonephropathy in rats are tend to be increased by ADR dosage and duration.