A Study of Glomerulonephropathy Induced by Adriamycin in Rats

Adriamycin is one of the most effective antitumor for carcinoma and sarcoma of variable internal organ. ADR induced cardiotoxicity has been reported as an serious complication. However recentely ADR induced nephrotoxicity has been documented in a variety of animal species. The present study was aimed to analyse the light and electron microscopic findings of renal glomeruli and tubules of rats treated by ADR. The results of the experiment are as follows: 1) The major histopathologic findings of Adriamycin induced glomerulonephropathy in rats are mesangeal thickeness and vacuolization of epithelial cell. 2) The major electron microscopic finding of ADR glomerulonephropathy in rats are focal or diffuse foot process fusion and vacuolization of epithelial microvilli. 3) Those light and electron microscopic glomerulonephropathy in rats are tend to be increased by ADR dosage and duration.