The Histopathologic and Immunohistologic Study on the Non-specific Benign Lymphadenopathy

This study was undertaken in an attempt to identify histopathologic and immunohistologic findings of non-specific benign lymphnode hyperplasia. The materials used in this suty consist of 169 cases of benign lymphnode hyperplasia in the lymphnode specimen dissected due to mass during the period of 6 years and 10 months in the department of pathology. The following results were obtained. 1) The ratio male to female was 1:1.2. The frequency was most common between 20 to 29 years old age with the percents of 24. 2) The most common type of benign lymphnode hyperplasia was diffuse hyperplasia(54 cases, 32%). The follicular hyperplasia was noted in 40 cases(24%), sinus histiocytosis in 36 cases(21%) and mixed pattern in 39 cases(23%). 3) The degree of diffuse hyperplasia, sinus histocytosis and mixed pattern was mild to moderate, while the severe degree was common in follicular hyperplasia. 4) The histopathologic findings associated with benign hyperplasia were necrosis, abscess and granulomas. 5) The immunohistologic stainings showed more frequent positive cells for IgG and IgA than positive cells for IgM. The frequency of positive cells for IgG and IgA was mild to moderate in follicular hyperplasia, diffuse hyperplasia and mixed pattern of lymphnode hyperplasia. IgM positive cells was mild in degree of frequency in diffuse hyperplasia, sinus histocytosis and mixed patterns.