The Effect of Naloxone on Pathological Changes in the Experimental Spinal Cord Injury

Kim, Sung Hak

doi:10.12771/emj.1988.11.4.299

Ewha Med J 1988; 11(4):299-309

pISSN: 1598-7450

DOI: https://doi.org/10.12771/emj.1988.11.4.299

Original Article

The Effect of Naloxone on Pathological Changes in the Experimental Spinal Cord Injury

Sung Hak Kim

Author Information & Copyright ▼

Department of Neurosurgery, College of Medicine, Ewha Womans University, Korea.

Corresponding author: Sung Hak Kim. Department of Neurosurgery, College of Medicine, Ewha Womans University, Korea.

Copyright ⓒ 1988. Ewha Womans University School of Medicine. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Published Online: Jul 24, 2015

Abstract

The object of this investigation was to study the effects of Naloxone on histopathological changes in cats subjected thoracic cord contusion. Twenty cats were divided 4 groups : The first group was sham control(3 Cats). The second group was the impact group that was induced by T₉ cord injury without treatment(6 Cats). The third group was the saline group that was induced by T₉ cord injury and treatment with Saline(6 Cats). The fourth group was the Naloxone group that was induced by T₉ cord injury and treatment with Naloxone(6 Cats). The histopathological evaluation of the injured spinal cords in Naloxone-treated Cats had less tissue damage than would be observed in time-matched standards. The histopathology in Saline-treated group had slightly better than typical of what we would expect in impact group.

Keywords: Spinal cord injury; Ischemia; Naloxone