Correlation MSI Status and Other Prognostic Factors in Sporadic Colorectal Cancer

Lee, Shi Nae

doi:10.12771/emj.2004.27.2.101

Ewha Med J 2004; 27(2):101-105

pISSN: 1598-7450

DOI: https://doi.org/10.12771/emj.2004.27.2.101

Original Article

Correlation MSI Status and Other Prognostic Factors in Sporadic Colorectal Cancer

Shi Nae Lee

Author Information & Copyright ▼

Department of Pathology, College of Medicine Ewha Womans University, Korea.

Copyright ⓒ 2004. Ewha Womans University School of Medicine. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Published Online: Sep 30, 2004

Abstract

Objectives

The purpose of this study was to evaluate MSI status in sporadic colorectal cancer and to correlate it with clinicopathologic variables.

Methods

Total 45 cases of surgically resected colorectal cancers retrospectively were reviewed about clinicopathologic findings and analyzed for micro satellite instability.

Results

The microsatellite instability (MSI) was found in 5 of 45 cases (11.1%) . A significant association was found between MSI+ tumors and location in the right colon (40%), and high histological grade (100.0%), and mucinous phenotype (33.3%). There was no significant difference for age, sex, growth pattern, lymph node metastases, vessel invasion, or Duke's stage.

Conclusion

These data indicate that MSI frequently occur in colorectal cancers of the right side and in tumors with poorly differentiated or mucinous histology.

Keywords: Colorectal cancer; Microsatellite instability; Clinicopathologic variables