A case of di Guglielmo syndrome in 9 year old boy was presented. This syndrome is characterized by excessive erythroid precursors with abnormal morphology both in the bone marrow and blood, and rare in childhood. He visited with the chief complaints of general weakness, weight loss, epistaxis and abdominal distension. Physical examination showed pallor, grade I-II/VI systolic murmur on apical area and marked abdominal distension with hepatosplenomegaly. we confirmed the patient by the peripheral smear and bone marrow aspiration.

3 cases of chronic Myelocytic Leukemia in children were seen during 5 year period 1973~1978. They were 6 year old male, 10 year old male and 12 year old female. On physical examination, pallor and splenomegaly were noted with nontender, hard and enlarged lymph nodes in the neck, axilla and inguinal region. They presented with a leukocytosis 100,000 per cumm~150,000 per cumm. The Philadelphia chromosomes were not detected. They in the chronic phase of chronic myelocytic leukemia responded well to busulfan. Maintenance of the hematologic remission has been possible with small daily doses of busufan.