Ninety patients(average age 18 years 10 months) with nevus flammeus were treated with the flashlamp pumped pulsed dye laser(Candela Laser Corp., Wayland, Mass., SPTL-1). With an average of 3 treatments, more than 75% lightening was achieved in 36 patients(40.0%), 50% to 75% lightening in 42 patients(46.7%), 25% to 50% lightening in 6 patients(6.7%), and less than 25% lightening in 6 patients(6.7 %), The percentage of lightening was increased as the number of treatments increased. The overall more than 50% lightening was achieved in 7 patients(l00%) of pink lesion treated, in 44 patients(89.8%) of red lesion treated, and in 27 patients(79.4%) of purple lesion treated.

There were complications such as cutaneous hyperpigmentations in 21 patients(23.3 %), hypopigmentations in 3 patients(3.3%). and atrophic scar in 1 patient(1.l%). All complications were transient and disappeared completely.

To evaluate correlation between the amounts of lipid peroxide in skin surface lipid and clinical aspect of lipid-relating cutaneous disorders, such as melasma and acne, skin surface lipid samples were collected by using cup method from the faces of 20 acne women and 20 melasma women, before and 3 months after topical treatment with 2% hydroquinone and 2.5% benzoyl peroxide, respectively. The amounts of total lipids and lipid peroxide in skin surface lipid were measured by spectrophotometer and statistically analyzed by student's t-test.

The results were as follows;

1) Before treatmentin comparison with control group, melasma group showed increase of the amounts of lipid peroxide and the ratio of lipid peroxide to total lipids. But acne group showed significant increase of the ratio of lipid peroxide to total lipids as well as the amounts of total lipids and lipid peroxide.

2) After treatment, in comparison with pretreatment, melasma group showed significant decrease of the amounts of lipid peroxide and the ratio of lipid peroxide to total lipids. And in acne group, the amounts of total lipids and lipid peroxide were also decreased significantly.

The amounts of lipid peroxide in skin surface lipid decreased at the time of improvements of clinical aspects in melasma and acne. This data suggest that clinical aspect of melasma and acne is related to the amounts of lipid peroxide in skin surface lipid.

Graular cell tumor is a rare benign lesion of unknown histogenensis.

A 51-year-old female had a 1.0cm sized, asymptomatic, firm nodule with erythematous, shiny, and smooth surface on her right side of posterior neck for 1 year. Excisional biopsy was done under the impression of epidermal cyst. The histologic specimen showed irregularly arranged dermal nests of large polyhedral cells containing small nuclei and coarsely granular eosinophilic granules within the pale cytoplasm. The granules were PAS-positive and diastase-resistant.

Recurrence was not found until 1 year after excisional treatment.