Dense deposit disease (DDD), known as type II MPGN, is an uncommon form of glomerulonephritis. It is an acquired primary glomerular disease, characterised by electron microscopic evidence of a continous, dense membrane deposition replacing the lamina densa. There is associated alternative pathway complement activation and a C3 nephritic factor maybe present. Patients with dense deposit disease tend to be young at clincal onset and more commonly have persistent nephrotic syndrome, gross hematuria, and acute nephritis episode and persistent depression of the serum complement level. The prognosis of dense deposit disease is worse than that of type I MPGN. We experienced a patient with dense deposit disease that presenting persistent nephrotic syndrome, gross hematuria and having subepithelial hump. It is a first report of dense deposit disease having subepithelial hump in Korea, therefore we report this case with the review of relevant literatures.
Coronary artery-to-left ventricular fistula is an unusual anomaly in adult and consists of a communication between one of coronary arteries and cardiac chambers. Most patients with coronary artery to ventricular fistulae are usually asymptomatic, but some can suffer from anginal pain. which can be caused myocardial ischemia due to coronary steal mechanism. In absence of concomitant atherosclerotic coronary artery disease or left ventricular hypertrophy causing an oxygen demand-supply imbalance, coronary steal appears to be a major importance in pathogenesis of myocardial ischemia in cases with generalized arterial systemic fistulae. We experienced 2 incidently found cases of coronary artery-to-left ventricular fistulae. We report these cases with a review of literature.