Xeroderma pigmentosum is a rare autosomal recessive disorder characterized by extreme photosensitivity and defect in repair of damage to DNA Lentigenes, freckles, telangiectasia and the hyperpigmented cutaneous macules in the sun-exposed area and early development of cutaneous malignancies are observed. In addition to cutaneous symptoms, ophthalmologic changes and neurologic abnormalities can be associated.

We report a case of xeroderma pigmentosum associated with squamous cell carcinoma in a 4-year-old girl. This case is thought to be more earlier development of malignancies than ever reported.

Merkel cell carcinoma is a rare aggressive tumor of uncertain origin. The tumor occurres most commonly in the head and neck region of the eldery.

The patient was a 62-year-old female with a reddish nonulcerative movable hard nodule on her left temple area for 2 months. Histopathologically, the tumor cells with large vesicular nuclei and scanty cytoplasm were arranged in trabecular and cord-like pattern in the dermis. The majority of the tumor cells were positive for neuron specific enolase, chromogranin and neurofilament.

The study was performed to get the basic knowledge about the changes of the cyclic AMP concentration and protein contents in cultured human melanocyte during 7 weeks of cultivation.

The results are as follows :

1) The concentrations of cyclic AMP were linearly increased from the 1st week to the 3rd week up to 8.l0×10^-5 pmoles/cell and 0.85 pmoles/mg of protein, which were found to be 2.88-fold and 1.73-fold larger than the those of the 1st week's cultivation. The concentrations of cyclic AMP then gradually decreased from the 3rd week to the 7th week of the cultured-lifespan.

2) The biosynthetic amount of protein was found to be 1.74×10^-5mg/cell on the 1st weekand 9.51×10^-5mg/cell on the 3rd week of cultivation. Values were gradually declined from the 3rd week to the 7th week of cultivation.

In the present investigation, it is clear that the amount of protein content and the concentration of cyclic AMP in the cultured human melanocytes derived form the epidermis of human skin were vividly increased up to the 3rd week of cultivation.

Thus, it might be suspected that the suitable time for the successful transplantation of cultured human melanocytes is around the 3rd week of cultivation.

We present herein a case of allergic granuloma due to cosmetic tattoo in eyebrow which developed in a 45-year-old female. She was seen with itching erythematous hard papules and plaques on the tattooing site.

Histopathologic findings reveled allergic granulomatous infiltration and brown pigment, and quantitative analysis by means of atomic absorption spectrophotometer were done with brown and black dye biospy specimen. 0.03 ppm chrome was found in the biospy specimen patch test was showed strong positive reaction to potassium dichromate.

We have tried intralesional injection of triamcinolone for 10 months with 3 weeks interval.

We present a case of squamous cell carcinoma arising in arsenic keratosis occuring in the hand and foot of 63-year-old male.

He had past history of arsenic ingestion and about fifteen years ago, several verrucous papules developed on the hand and foot. But on left sole, aggravating erosive lesion developed. The histopathologic study showed finding of squamous cell carcinoma. Excision and skin graft was done and we are following now.

We present two cases of childhood dermatomyositis. Case 1 was a 4 year old girl who developed erythematous swelling on the face, violaceous papules on the dorsum of the hands, and progressive muscle weakness which led to walking difficulty. Case 2 was a 11 year old girl who had diffuse erythematous confluent patches with fine scales on the face. Poikilodermatous changes on the whole body and progressive muscle weakness in lower extremities developed. These cases were confirmed by clinical appearance, laboratory findings and histopathologic findings.