The connecitve tissue nevus represents a hamartoma of various components of dermal connective tissue elements, predominantly collagen, elastin or glycosaminoglycans. We present a case of connective tissue nevus on both hands, right elbow, right knee area. This case was a 9-year-old male who have had skin colored or yellowish plaques without subjective symptoms and there was no trauma histroy.

Langerhans cells are immunocompetent, dendritic cells of bone marrow derivation that reside within the epidermis. Langerhans cells have been implicated as playing a key role in the processing and presentation of antigens to lymphocyte in contact allergic cell-mediated immune reactions.

The present study was undertaken in order to clarify the effect of topical glucocorticosteroids on the number and the morphological alterations of epidermal Langerhans cells. Three kinds of topical glucocorticosteroids with different potency were applied to the back of guinea pig twice. a day for 14 days. Skin specimens were taken 2nd, 7th, 14th day of the application and 7th day after cessation of application. The ATPase stain and electron microscopic observations were performed to assess the numbers and morphological alterations of epidermal Langerhans cells.

The following results were obtained:

1) The number of epidermal Langerhans cells significantly decreased after 7 days applications of glucocorticosteroids in all experimental groups compared with control(p<0.05).

2) In each experimental group, the decrease of the number of epidermal Langerhans cells was more significant in 0.5% concentration than those in 0.1% concentrations(p<0.05).

3) The difference of effects on Langerhans cell density between corticosteroids was significant(p<0.05).

4) The morphological changes of epidermal Langerhans cells were prominent from 7th day of the application of glucocorticosteroids. Many Langerhans cells showed shortness of dendritic processes, decreased staining properties, enlargement of nuclear chromatin, swelling of mitochondria, dilatation of perinuclear cisternae and endoplasmic reticulum.

In summary, decrements in Langerhans cell density were correlated with the concentration and potency of the topical glucocorticosteroids.

We present two cases of pityriasis lichenoides et varioliformis acuta occurring on the whole body. The case 1 was a 13 year old male who have had papulosqamous, hemorrhagic lesions and were treated by tetracyclines. The other case was a 32 year old female who have had scaly erythematous papules and were treated by etretinates.

Pemphigus erythematosus(Senear-Usher syndrome) was originally described by Senear and Usher as a type of pemphigus with features of lupus erythematosus. We present two cases of pemphigus erythematosus on the face and trunk. The case 1 was a 41-year-old female who have had erythematous scaly patches and a few flaccid bullae, and treated by corticosteroids and azathioprine. The case 2 was a 42-year-old male who have had same lesions and treated by corticosterids.