| Jung En Park | 2 Articles |
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[English]
In the past gastric carcinomas composed predominantly of signet ring cells formed only a small percentage of gastric malignancies. However. we have had the impression that in recent years the relative incidence and amount of signet ring cells in biopsy and resection specimens of gastric carcinoma have risen sharply. This report is an analysis of 69 cases of signet ring cell type of gastric adenocarcinoma diagnosed at Ewha Womens University Hospital from January, 1987 to December, 1991. The results obtained were summerized as follows. 1) The male to female ratio was 1:1.2. 2) The peak age incidence was the 6th decade and the 7th decade with 23.9% each other, and the 8th decade with 17.4%, the 5th decade and the 4th decade with 16% each other. Average age of patients was younger than entire gastric adenocarcinoma. 3) The major clinical symptom was epigastric pain, indigestion, vomiting and abdominal fullness in decreasing orders. 4) The macroscopic feature of the signet ring cell type of adenocarcinoma by gastronberscopy showed Borrmann's type III 26 cases(37.6%), type IV 21 cases(30.4%), type II 10 cases(14.5%). 5) The location of signet ring cell type was mainly the gastric antrum 39 cases(56.5%), the body 18 cases(26%), and widespread from body to antrum 9 cases(13%). 6) The size of lesion showed above 3cm with 53%, 1.5~3.0cm with 31.3%, below 1.5cm with 15.7% in frequency. 7) Thirty out of 39 cases(76.9%) involve to the serosa, 3 cases(7.7%) to the muscle layer, 3 cases(7.7%) to the mucosa and the submucosa each other. 8) Distant metastases were relatively frequently occurred in increased CEA group. 9) Five-year survival rate of 49 cases was 62.8%.
[English]
Ulcerative colitis is an waxing and waning inflammatory bowel disease characterized by rectal bleeding and diarrhea, affecting principally the mucosa of the rectum and colon. Its incidience is being higher in Europe and America and it also seems to be rising increasingly in our country because diagnostic methods are much developed and Korean life styles are westernized. So, we investigated its clinical characteristics. We analyzed 36 cases of ulcerative colitis which had been treated in the Hospital of Ewha Womans' University from Jan. 1983 to Feb. 1993, retrospectively. 1) The most prevalent age group was 3rd decade and male to female ratio was 1:1.77. 2) The duration of symptoms was less than 6 months in 63.9%. 3) The most common clinical manifestation was hematochezia(86.1%), abdominal pain(75.0%), diarrhea(72.2%), fever(30.6%), weight loss(27.8%) in the order of frequency. 4) According to the severity, moderate type was shown in 52.8%, severe in 33.3% and mild in 13.9%. 5) According to the anatomical distribution of the lesion, pancolitis was shown in 36.1%, the involvement of the rectum and sigmoid colon in 16.6%, the left-sided colon in 13.8%, rectum only in 13.8%, transverse colon in 8.3% and backwash ileitis in 11.1%, respectively. 6) The hematologic laboratory finding was non-specific including anemia, leukocytosis, increased erythrocyte sedimentation rate, bypoalburninemia, electrolyte imbalance, increased serum transaminase and alkaline phosphatase. 7) Colonoscopy revealed ulceration(77.1%) commonly, including hyperemia(51.4%), bleeding(42.5%), mucosal friability(22.9%), pseudopolyp(22.9%), granularity(20.2%). 8) The Barium enema showed granularity commonly and loss of haustral marking(55.2%), luminal narrowing(34.5%), lead pipe rigidity(13.8%), pseudopolyp(3.4%). Also, normal finding was shown in 10.3%. 9) The most common histopathologic finding was inflammation(83.3%) and ryptitis(55.6%), ulceration(50%), goblet cell depletion(19.4%), pseudopolyp(19.4%), necrosis(13.9%), granolarity(8.3%) were also noted. 10) With the medical treatment, 76.5% of the cases showed initial improvement of the symptom, but the recurrence developed in 17.7%. The surgery was performed in 6 cases of patients(16.7%). Emergency operation was performed in 2 cases due to bowel perforation and elective operation in 4 cases.
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, Seock Ah Im
