Cytomegalovirus (CMV) infection in immunocompromised patients is associated with significant morbidity, mortality, and adverse clinical outcome. However, CMV infection in immunocompetent patients has been considered to have subclinical and self-limited course, and does not require treatment. We reports a case of CMV colitis, presented with colon perforation and lower gastrointestinal bleeding in a immunocompetent 31-year-old young male. After conservative treatment, colonoscopy revealed multiple ulcers in transverse colon. CMV colitis was confirmed by microscopic findings and immunohistochemistry. After successful treatment with ganciclovir, the patient improved without invasive procedure.

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• Gastric Ulcers with Cytomegalovirus Infection in an Immunocompetent Patient
  Tae Oh Kim, Ki-Nam Shim, Sang Yoon Kim, Ji Young Lim, A Reum Choe, Chung Hyun Tae, Chang Mo Moon, Seong-Eun Kim, Hye-Kyung Jung, Sung-Ae Jung
  The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2019; 19(4): 277.     CrossRef
• Conservative treatment of cytomegalovirus colitis with bowel perforation in an immunocompetent patient: case report and review of literature
  Kyoung Sik Nam, Hee Ug Park, Min Gi Park, Su Ho Park, Ji Yeon Hwang, Dong Kyu Kim, Sung Jun Kim
  Yeungnam University Journal of Medicine.2017; 34(1): 75.     CrossRef

The rearrangement of c-ros oncogene 1 (ROS1) has been recently identified as an important molecular target in non small cell lung cancer (NSCLC). ROS1 rearrangement and epidermal growth factor receptor (EGFR) mutation were mutually exclusive each other in previous studies, and the clinical implication of co-existence of the two genetic alterations has not been determined. We report a case of 46-year-old female never-smoker NSCLC patient whose tumor harbored ROS1 rearrangement and EGFR mutation concomitantly. She had undergone curative surgery for stage IIIA NSCLC, and the recurrence in left pleura and brain occurred at 2 years after the surgery. She received several lines of chemotherapy including docetaxel plus carboplatin, erlotinib, pemetrexed, and gemcitabine. Erlotinib therapy showed a favorable treatment response with progression-free survival of 9.5 months and partial response of tumor on radiologic evaluations. This case represents a successful erlotinib treatment in a NSCLC patient with concurrent ROS1 rearrangement and EGFR mutation.

With the aging population, more patients who have undergone previous coronary artery bypass grafting (CABG) are surviving long enough to require subsequent aortic valve replacement (AVR). Conventional redo AVR after prior CABG involves resternotomy, dissection and clamping of the patent bypass graft vessel. Favorable results have been reported for AVR following previous CABG; however, the problems of this procedure includes that injury to the patent bypass grafts can result in catastrophic complications. Increasing patient age and comorbidities may increase operative mortality, less invasive percutaneous aortic valve intervention has advanced. However, because there are no sufficient data comparing transcatheter aortic valve intervention with surgical AVR, currently, the surgical approach should still be consider as the standard of treatment for AVR following previous CABG. We report a patient in whom successful conventional AVR was underwent after previous CABG with patent left internal mammary artery.

Vibrio cholerae is mainly known to cause gastrointestinal infection after seawater exposure or raw seafood intake. It is rarely reported to cause cellulitis or sepsis, but threre has been no known case after acupuncture. Herein, We report a 56-year-old cirrhotic patient of non-O1, non-O139 Vibrio cholerae septicemia caused by cellulitis of both lower extremities after acupuncture.

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• Publication status and reporting quality of case reports on acupuncture-related adverse events: A systematic reviews of case studies
  Tae-Hun Kim, Myeong Soo Lee, Stephen Birch, Terje Alræk, Arne Johan Norheim, Jung Won Kang
  Heliyon.2023; 9(10): e20577.     CrossRef
• A Fatal Case of Bacteremia Caused by Vibrio cholerae Non-O1/O139
  Soyoon Hwang, Yoonjung Kim, Hyejin Jung, Hyun-Ha Chang, Su-Jeong Kim, Han-Ki Park, Jong-Myung Lee, Hye-In Kim, Shin-Woo Kim
  Infection & Chemotherapy.2021; 53(2): 384.     CrossRef
• Non-O1, non-O139 Vibrio cholerae bacteremic skin and soft tissue infections
  Sofia Maraki, Athanasia Christidou, Maria Anastasaki, Efstathia Scoulica
  Infectious Diseases.2016; 48(3): 171.     CrossRef
• The Reporting Quality of Acupuncture-Related Infections in Korean Literature: A Systematic Review of Case Studies
  Tae-Hun Kim, Jung Won Kang, Wan-Soo Park
  Evidence-Based Complementary and Alternative Medicine.2015; 2015: 1.     CrossRef
• Vibrio Vulnificus Necrotizing Fasciitis Associated with Acupuncture
  Yael Kotton, Soboh Soboh, Naiel Bisharat
  Infectious Disease Reports.2015; 7(3): 5901.     CrossRef