Granular cell tumor(GCT) is an uncommon tumor characterized clinically by an asymptomatic, solitary nodule in the tongue and skin, especially head and neck region. Histopathologically the broad fascicles of tumor cells infiltrate the dermis and the tumor cells are characterized by plump cells with faint eosinophilic, granular cytoplasm.
The origin of cells has been debated for decades. However electron microscopic and immunohistochemical studies strongly support a Schwann cell origin.
We report a case of granular cell tumor arising from the anterior chest of 12-year-old healthy girl, which exhibited the distinctive histopathologic appearance and also reactive with PAS, S-100, and NSE.
Cutaneous periarteritis nodosa is a chronic and benign vascular disease in which cutaneous lesions are perdominent without visceral involvement.
We report a case of cutaneous periarteritis nodoas in a 8-year-old boy who presinted tender plaque with hemorrhagic ulceration and telangiectatic patches on the inner side of the right thigh with no visceral involvement. Histologic examination showed panarteritis of small and medium-sized arteries at the dermal-subcutaneous junction.
The patient was treated with prednisolone and dapsone with a good clinical response.