The utilization of acetate & bicarbonate dialysate and their effects on acid-base balance, blood pressure, pulse rate, serum cholesterol, triglyceride, HDL and free fatty acid were investigated during regular hemodialysis.

Eight patients with chronic renal failure were studied during two successive dialysis treatments for which either acetate or bicarbonate were used as a buffer anion in the dialysate.

The result obtained as follows :

1) There was no significant difference in arterial pH between acetate and bicarbonate hemodialysis patients.

2) Arterial HCO₃ was higher significantly in patients with bicarbonate hemodialysis than acetate hemodialysis from 60 to 240 minutes (p<0.01)

3) Arterial pCO₂ fell significantly from 34.0 mmHg to 31.7 mmHg during acetate hemodialysis patient (p<0.01)

4) Heart rate rose signifificantly from 69 b.p.m to 82 b.p.m. during acetate hemodialysis(p<0.01).

5) Serum fatty acid increased significantly during acetate and bicarbonate hemodialysis, but no difference between two groups.

6) There were no significant changes in systolic and diastolic blood pressure in two groups during hemodialysis.

7) There were no significant changes in serum cholesterol, triglyceride and HDL in two groups during hemodialysis.

A Clinical study on 94 cases of primary liver cancer who were confirmed at Ewha Womans University Hospital from January 1984 to December 1986 was carried out. The result obtained are as follows: 1) The ratio of male to female is 3.9 : 1, and highest incidence rate is 42.6% in 6th decade. 2) The chief complaints are RUQ abdominal pain, epigastric discomfort, dyspepsia, weight loss in the decreasing order. Physical examination shows hepatomegaly, ascites and jaundice. 3) Clonorchis sinensis infestation reveals 8.5% of cases. 4) Liver function tests shows serum globulin elevation in 96.8%, AST(aspartate aminotransferase, SGOT) elevation in 91.5%, alkaline phoaphatese elevation in 86.2%, in order of frequency. 5) Alpha-fetoprotein is positive (>400ng/ml) in 72.3% of cases. 6) Serum HBsAg is positive in 75.0% of cases. 7) Alpha-fetoprotein is apt to be positive in the HBsAg positive cases. 8) Space occupying lesions are demonatrated by liver scanning in 93.6% of cases: 73.9% in the right lobe, 11.4% in the left lobe and 14.7% in the both lobes. 9) Twelve (70.6%) of cases are assoiated with cirrhosis of liver. Of cases 75.0% is macronodular.