No abstract available.

Binding of the hepatocarcinogen 2-acetylaminofluorene(AAF) to the DNA of rat liver homogenates was examined in vivo. Animals fed low and high concentrations vitamin A and E for 28 days and DNA isolated 2 hr following a single i.p. injection of[9-¹⁴C]acetylaminofluorene. The precipitated DNA was dissol-ved in MUP, blended and passed through an HAP column. UV-absorbing material eluted with 0.48M Nap. Following dialysis, the fraction was enzymatically hydrolyzed purified by Sephadex LH-20 chromatography and the adducts were separated by HPLC. The ability of vitamin A and E on the binding of AAF to liver DNA in vivo was markedly inhibited the formation of the proximate carcinogen, N-(deoxyguanosine-N²-yl) AAF(C-8 adduct). Vitamin A at higher concentration(2,000I.U.)exerted a stronger inhibitory effect on the formation C-8 adducts. A similar inhibition pattern was observed in higher concentration vitamin E administered rats. The data presented here demonstrated marked inhibits in the pattern of C-8 deoxyguanosine adduct formation during the premaligment phase of 2-AAF carcinogenesis.

The antidiarrheal effects of Lidamidine was observed in 30 cases of acute and chronic diarrhea between Mar. '85 and May '85. The following results were obtained. 1) Overall evaluation of therapy was rated by physician and patient at the end of the study revealed excellant control in 50%, good control in 30%, fair control in 15% and poor in 5% of the cases and in placebe 10 of 10 cases all revealed no effect. 2) Vital signs were stable and all laboratory findings including CBC, urinalysis, liver function test revealed no significant change during the treatment. 3) Mean daily dose were 32.3±29.4mg. 4) There was no side effect of Lidamidine Hydrochloride. 5) Mean duration of treatment were 4.5±1.5 days.

It is well known that the continuous irrigation method is effective to control the pyogenic osteomyelitis. However, there are no reports concerning the period of continuous irrigation method as to how long the method is applied for treating the pyogenic osteomyelitis. Some authors have determined its period depending on patient's conditions, characteristics of draining fluid and results of bacterial culture. Therefore, this experiment was performed to determine the physiological or pathological effects of the continuous irrigation to the normal bone and the time when the effects to normal bony tissue happened. In author's tudy, 30 house rabbits are used for determining the period that the normal bone is pathologically changed by experimental continuous irrigation method. The continuous irrigation in normal femoral shaft bone of rabbit set up dead bone formation began at the early of 5 weeks so in diseased bone such as osteomyelitis is the period of the continuous irrigation may be shorter than that of normal bone. I assumed that the period of the continuous irrigation sustaining 4 week-duration may not be occurred any problems to bony tissue.

Acute experimental occlusions of the left middle cerebral artery of cats were accomplished by applying the Heifets zlip through the retro-orbital extradural approach with operating microscope. The most striking neurologic signs were disturbance of consciousness, paresis of the right limbs(especially fore limb), and tonic deviation of the head neck toward the side of the occluded artery. The size and severity of the infarcts generally were related to the severity of the neuro logic disorders. 4 cats died within 48 hours of the occlusion of artery and 5 cats improved somewhat after the initial stage. However, the disturbance of the consciousness and the motor weakness persisted until the end of the period of observation. The severity of persistence of the neurological deficits may depend upon the effectiveness of reperfusion through collateral channels and the variability of anatomical pattern of the cerebral structures. A disturbances of consciousness may be related to the generalized decreases of neuronal activity or to focal neuronal dysfunction. Ischemic edema secondary to brain ischema increases the intracranial pressure and aggravates the impairment of neurological deficits. Finally cerebral herniation may produce the irreversible brainstem damage and death. Therefore, early reperfusion of ischemic brain before ischemic edema develops may improve the neurological deficts and prevent the occurrence of the secon-dary neuronal dysfunction.

Hemorrhoidectomies with lateral internal partial sphincterotomy were performed for selected patients with hemorrhoid and following results were obtained. 1) There was no difference in sexual distribution, and patients were predominated in active age group. 2) Mainly, patients complained prolapse(61.8%), bleeding(57.3%), and pain(35.5%). 3) Postoperative complaints were pain relieved by administering the analgesics(27.3%), urinary retention required urinary catheterization(29.1%), and constipation required laxatives(17.3%). 4) Postoperative complications were minimal hemorrhage(6.4%), delayed healing process(0.9%), and no strict or incontinence was observed. 5) Average postoperative hospital stay was 4.2 days.

Dermatofibrosarcoma protuberans(DFSP) is an uncommon, raised, fibrous tumor of the skin characterized by a marked tendency to recur locally infrequent metastasis and difficulty of histologic diagnosis. There are several cases reporting origin of this tumor in a previous burn or surgical scar raised the question of a causal relationship. The authors report a case of DFSP, developed in an old burn scar of a 58-year-old man. There was no evidence of metastasis.