The effect of intraperitonelly administered higenamine on the cytochrome P -450, b₅, P-nitroanisole-O-demethylase and lipid peroxidation in the rat hepatic microsomes were determined. The following results were obtained ; 1) The intraperitonelly administered higenamine increased contents of rat hepatic microsomal cytochrome P-450 and b₅. 2) The principal role of cytochrome P-450 in mixed function oxidase reactions includes hydroxylation of various drugs, fatty acids, steroids, pesticides and carcinogens. The increased cytochrome P-450 induced by higenamine decreased on the both AAF of N-hydorxylation and Ring-hydroxylation. 3) Activity of P-nitroanisole-O-demethylase in hepatic microsomes with higenamine was decreased accorting to incresed dosage of higenamine. 4) The formation of lipid peroxides was increased according to increased dosage of higenamine.

The effectiveness of phototherapy in the treatment of neonatal hyperbilirubinemia is so established that it is widely used without serious side effects. The widespread use of phototherapy has caused some concern since substances other than bilirubin may be photocativated or photodecomposed. The toxic properties of these photoactivated substances might prove to be more harmful to the neonatal infants than bilirubin. The purpose of the present study was to investigate the photodynamic metabolic effects on the hepatic microsomal cytochrome P-450, cytochrome b₅, riboflavin status, hepatic microsomal DNA and RNA of newborn rats at 1 week and 3 weeks of illumination by phototherapy lights. The results are as follows: 1) Activities of hepatic microsomal cytochrome P-450 and cytochrome b_5 in newborn rats increased significantly at 3 weeks of illumination by phototherapy lights. 2) Induced cytochrome P-450 by phototherapy lights increased the ring-hydroxylation of AAF. more significantly(P<0.001) than the N-hydroxylation(P<0.01). 3) Erythrocyte glutathione reductase activity coefficient as a measure of riboflavin status increased significantly(P<0.05) at 1 and 3 weeks of illumination by phototherapy lights, and this means the riboflavin deficiency due to the photodecomposition of riboflavin by phototherapy lights. 4) The quantative measurement of hepatic microsomal DNA and RNA showed no significant change by phototherapy lights.

Acetabulum is very important in weight bearing and maintaining the normal contour for the function of hip joint. Acetabular fractures are uncommon, because of incongruity, displaced acetabular fractures result in early post-traumatic osteoarthritis. Anatomical reduction and stable internal fixation of acetabular fracture improves the prognosis of the displaced fracture, but the internal fixation of acetabular fracture still represents one of the most difficult tasts in hip surgery. During the period of June 1975 to June 1984, 52 cases were treated in the Department of Orthopaedic Surgery, Ewha University College of Medicine, and results were summarized as follows,1) In the treatment methods of the acetabular fracture, I couldn't assert firmly that a surgical treatment was more desirable than a conservative one when I valued their results. And so, I have chosen the formation for a severe degree of fractures or in accordance with fracture-sites, and adapted the latter for a severe comminuted or non-displaced fracture. 2) The posterior wall acetabulum or the displaced fracture of a dome could be accurately reduced by a possible operation which was considered as a helpful treatment method in preventing the traumatic arthritis for the prognosis. 3) There was no avascular necrosis of femoral head among 52 cases. 4) In case which was difficult to be reduced on author's operation procedure, the fracture could be easily reduced with a born-hook in drill hole, and also the new fixation was effective by inserting screws into the main fragment and wiring them together not to move in case difficult to be fixed. 5) The Marvin Tilie's classification was of use in selecting the conservative treatment or the surgical one.

The object of this investigation was to study the effects of mannitol and high dose of methylprednisolone(MP) upon evolution of cerebral infarction in cats after acute left middle cerebral artery(MCA) occlusion and following reperfusion. The acute occlusion of left proximal MCA of thirty cats for 2, 4 and 6 hours respectively were accomplished by applying the Heifetz clip through the retro-orbital extradural approach and followed by 2 hours of recirculation. Fifteen cats were untreated as a control group and the fifteen cats were given a combination of mannitol(2g/kg) and MP(15mg/kg) at 30 minutes after occlusion initially, and then every one and half hour. Results of morphologic examination of the brain demonstrated that in treated cats undergoing 2-hour or 4-hour occlusion mannitol and MP improved the ischemic edema and infarction, but in treated cats undergoing 6-hour occlusion they had little protective effect in ischemic brain injury(swelling, neuronal damage and hemorrhagic infarction). Electroencephalography(EEG) in cats undergoing 2- or 4-hour occlusion showed more increasing activities and voltage than in untreated groups, but in cats undergoing 6-hour occlusion low voltage and slow waves with poor activity, i.e, generally suppressed pattern, were observed and were not significantly different between treated and untreated groups. Our experimental studies of the therapeutic beneficial effects of mannitol and MP were observed in cats of 2- or 4-hour occlusion of MCA with 2 hour recirculation Therefore, it was suggested that mannitol and MP will prolong the period of potential reversibility of cerebral ischemia following reperfusion within 4 hours of ischemia.

Myxoma of the left atrium is known to mimic the clinical and hemodynamic features of mitral valvular disease. The tumor was diagnosed by using the Echophonocardiography, CAT-scanning, and hemodynamic studies including left heart catheterization and angiography. The diagnosis was confirmed at operation. An electrocardiographic timing signal permitted correlation of heart sounds and pressure waves with movement of the tumor between the left atrium and the left ventricle. In early systole, the tumor suddenly moved from left ventricle to the left atrium, and a notch in the rising left ventricular pressure, a prominant c-wave, and loud, late element of the first heart sound were noted. In early diastole, the tumor moved rapidly through the mitral valve, causing an abrupt diminution in the left atrial volume, thus-causing rapid y-descent despite severe obstruction of the mitral valve. An early diastolic sound, thought to be an opening snap, appeared to be related to the checking of the tumor in the left ventricle.(Tumor plop). The unusual left atrial pressure pulse permits accurate preoperative diagnosis in left atrial myxoma. In this respect we evaluated the accuracy of the preoperative noninvasive studies for the diagnosis of intra-cardiac myxoma.

We presented here a patient of autoimmune hemolytic anemia associated with systemic lupus erythematosus. This 38 year old female was admitted because of dizziness and dyspnea. In peripheral blood and bone marrow study, characteristics of autoimmune hemolytic anemia were seen. And she was well treated with prednisolone only. The general concept of autoimmune hemolytic anemia with the brief review of literature is discussed.