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"Enhanced recovery after surgery"

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"Enhanced recovery after surgery"

Review articles

[English]
Personalized perioperative pain management: a narrative review
Min Kyoung Kim, Hyun Kang
Ewha Med J 2025;48(4):e62.   Published online September 16, 2025
DOI: https://doi.org/10.12771/emj.2025.00773
Perioperative pain management has shifted from standardized, procedure-based protocols toward individualized, patient-centered approaches. Inadequate pain control can result in short-term adverse outcomes, including delayed ambulation, prolonged hospitalization, and increased complications, as well as long-term sequelae such as chronic persistent postsurgical pain. Early models of preemptive and preventive analgesia emphasized pain relief primarily through the use of opioids. Growing concern about opioid-related adverse effects established the basis for multimodal and opioid-sparing strategies. Nevertheless, with the onset of the global opioid crisis, heightened awareness of the risks of opioid overuse has fueled interest in opioid-free techniques. However, evidence does not demonstrate that opioid-free methods are superior to opioid-sparing approaches. This underscores the importance of returning to the central goals of enhanced recovery after surgery: early restoration of function and reduction of complications. Within this framework, personalized pain management has emerged as a practical paradigm that tailors interventions to individual characteristics, including comorbidities, psychological status, pain sensitivity, and recovery objectives. This review outlines the rationale, current practices, and future directions of personalized perioperative pain management and proposes a framework for integrating new strategies into clinical care.

Citations

Citations to this article as recorded by  
  • Personalized Multimodal and Opioid-Sparing Analgesia for Postoperative Pain Management: Enhancing Recovery and Addressing the Post-Discharge Gap
    Marie Louise Sezerano, Emery Niyonkuru
    Journal of Pain Research.2026; Volume 19: 1.     CrossRef
  • Future directions in anesthesia: expanding the role of anesthetic drugs in sedation, analgesia, and recovery
    Min Kyoung Kim, Hyun Kang
    Journal of the Korean Medical Association.2026; 69(4): 294.     CrossRef
  • Effect of lidocaine on acute pain after modified radical mastectomy: a secondary analysis of a randomized trial
    Jiao Liu, Wenjuan Zhang, Xiaohui Li, Danting Jia, Zhixia Bai, Xuexin Chen
    Frontiers in Medicine.2026;[Epub]     CrossRef
  • 3,067 View
  • 79 Download
  • 3 Web of Science
  • 3 Crossref
[English]
Two paths, one goal–uniting regional and general anesthesia for optimal surgical care: a narrative review
Min Kyoung Kim, Oh Haeng Lee, Hyun Kang
Ewha Med J 2025;48(4):e61.   Published online September 16, 2025
DOI: https://doi.org/10.12771/emj.2025.00724
The integration of regional anesthesia (RA) with general anesthesia (GA) has become a central component of multimodal strategies to improve perioperative pain management. This approach not only enhances analgesic efficacy but also reduces opioid requirements and mitigates opioid-related adverse effects. By targeting peripheral or neuraxial nociceptive pathways, RA attenuates the surgical stress response and decreases central sensitization, complementing the systemic actions of GA. The combined application of RA and GA has shown substantial benefits across a wide range of surgical procedures, including abdominal, thoracic, orthopedic, and pediatric operations. Reported advantages include improved hemodynamic stability, enhanced pulmonary function, earlier ambulation, faster gastrointestinal recovery, and greater patient satisfaction. Moreover, recent evidence indicates a positive association between effective postoperative pain control and long-term outcomes, such as reduced incidence of persistent postsurgical pain, better functional independence, and even improved immune function and survival following cancer surgery. The development of sustained-release local anesthetic delivery systems, which provide localized and prolonged analgesia, further extends the benefits of RA-GA integration into the postoperative period. This review summarizes the mechanistic rationale, clinical applications, and future directions of RA-GA combinations in modern surgical care, with special emphasis on their role in enhanced recovery after surgery protocols.

Citations

Citations to this article as recorded by  
  • Results and Future Perspectives of the Sustainable Anesthesia Project: A Large-Scale, Real-World Implementation Study at the Largest Spanish Private Healthcare Provider
    Juan Acha-Ganderias, María del Pino Henríquez-de Armas, Luis Enrique Muñoz-Alameda, Ion Cristóbal, Cristina Caramés, Leticia Moral-Iglesias
    Healthcare.2026; 14(3): 300.     CrossRef
  • Effect of transcutaneous electrical nerve stimulation on patients after coronary artery bypass grafting: a systematic review and meta-analysis
    Enyu Zhang, Jihe Kang, Yan Liu, Lulu Wang, Bo Wan, Xiaoling Li
    Frontiers in Cardiovascular Medicine.2026;[Epub]     CrossRef
  • From repair to reconstruction: a holistic perspective in abdominal wall hernia surgery
    Xin-liang Hou, Ting Zeng, Xu Wang, Li-ye Tan
    Frontiers in Surgery.2026;[Epub]     CrossRef
  • Future directions in anesthesia: expanding the role of anesthetic drugs in sedation, analgesia, and recovery
    Min Kyoung Kim, Hyun Kang
    Journal of the Korean Medical Association.2026; 69(4): 294.     CrossRef
  • Letter to the Editor re “Opioid Prescribing Patterns and the Effect of Chronic Kidney Disease in Pediatric Urology Population: A Retrospective Cohort Analysis”
    Yashkumar Kiranbhai Rajvi, Mohit Kumar, Shubham Singh
    Journal of Pediatric Urology.2026; : 105964.     CrossRef
  • 4,266 View
  • 63 Download
  • 4 Web of Science
  • 5 Crossref
[English]

Enhanced recovery after surgery (ERAS) protocols are designed to minimize surgical stress, preserve physiological function, and expedite recovery through standardized perioperative care for primary colorectal surgery patients. This narrative review explores the benefits of current ERAS protocols in improving outcomes for these patients and provides insights into future advancements. Numerous studies have shown that ERAS protocols significantly reduce the length of hospital stays by several days compared to conventional care. Additionally, the implementation of ERAS is linked to a reduction in postoperative complications, including lower incidences of surgical site infections, anastomotic leaks, and postoperative ileus. Patients adhering to ERAS protocols also benefit from quicker gastrointestinal recovery, marked by an earlier return of bowel function. Some research indicates that colorectal cancer patients undergoing surgery with ERAS protocols may experience improved overall survival rates. High compliance with ERAS protocols leads to better outcomes, yet achieving full adherence continues to be a challenge. Despite these advantages, implementation challenges persist, with compliance rates affected by varying clinical practices and resource availability. However, the future of ERAS looks promising with the incorporation of prehabilitation strategies and technologies such as wearable devices and telemedicine. These innovations provide real-time monitoring, enhance patient engagement, and improve postoperative follow-up, potentially transforming perioperative care in colorectal surgery and offering new avenues for enhanced patient outcomes.

Citations

Citations to this article as recorded by  
  • Implementation of Modified Enhanced Recovery After Surgery Protocols for Elective Incisional Hernia Repair After Damage Control Surgery: A Retrospective Observational Study
    Marharyta Smirnova, Oleh Herasymenko, Mykhailo Koshikov, Vitalii Melnyk, Alim Ulukhanov
    Journal of Abdominal Wall Surgery.2026;[Epub]     CrossRef
  • Compliance with an enhanced recovery pathway and postoperative outcomes in elderly colorectal cancer patients: a real-world cohort and structural pathway analysis
    Liping Feng, Qingyong Huang, Songchun Liu, Shuang Wu
    Updates in Surgery.2026;[Epub]     CrossRef
  • Enhanced recovery after surgery protocol: impact on postoperative recovery and complications
    Jennifer N. M. Cassemiro, Alex G. T. Gonçalves, Ana J. S. Ribeiro, Daphne C. Feliciano, Erick S. Q. Santos, Gabriela A. V. de Oliveira, Lara S. Alencar, Luiza M. Rossi, Ricardo H. Michel
    International Surgery Journal.2026; 13(6): 1009.     CrossRef
  • Risk factors for prolonged postoperative ileus in elderly patients undergoing laparoscopic radical resection for colorectal cancer
    Huan Liu, Yang Chen, Shi-Gang Guo, Zhu Liu, Yong-Shuai Huang, Zhen-Dong Zhu, Yu-Jie Feng, Qing Yang, Ya-Lei Liu
    World Journal of Gastrointestinal Oncology.2026;[Epub]     CrossRef
  • ERAS Implementation Fidelity, Care Complexity, and Postoperative Outcomes in Oncological Colorectal Surgery: A Real-World Observational Study
    José Antonio Jerez González, Miguel Ángel Hidalgo-Blanco, Montserrat Puig Llobet, Jordi Adamuz, Maria Eulàlia Juvé-Udina, Oliver Polushkina-Merchanskaya, Bernat Miguel-Huguet, Mireia Mariscal Cabeza, Carmen Moreno Arroyo
    Healthcare.2026; 14(11): 1519.     CrossRef
  • A cost comparison between patients undergoing robotic colorectal surgery with and without a clinical pathway
    Alfonso Valenzuela Hurtado, Onur Bayram, Jörg Kleeff, Johannes Klose, Manuela De Allegri, Ulrich Ronellenfitsch
    Cost Effectiveness and Resource Allocation.2026;[Epub]     CrossRef
  • Impact of “Enhanced Recovery After Surgery” (ERAS) protocols vs. traditional perioperative care on patient outcomes after colorectal surgery: a systematic review
    Vaishnavi Kannan, Najeeb Ullah, Sunitha Geddada, Amir Ibrahiam, Zahraa Munaf Shakir Al-Qassab, Osman Ahmed, Iana Malasevskaia
    Patient Safety in Surgery.2025;[Epub]     CrossRef
  • 12,049 View
  • 119 Download
  • 5 Web of Science
  • 7 Crossref
Review Article
[English]

Enhanced recovery after surgery (ERAS) aims to promote postoperative recovery in patients by minimizing the surgical stress response through evidence-based multimodal interventions. In 2023, updated clinical practice guidelines were published in North America, potentially superseding the most recent guidelines previously announced at the ERAS Society in 2019. This review compares and reviews these two guidelines to examine the principle of ERAS and items related to colorectal surgery and to introduce the latest relevant study results published within the last 5 years. In the pre-hospitalization stage, the concept of pre-hospitalization is emphasized; this involves checking and reinforcing the patient’s nutritional status and physical functional status before surgery. In the preoperative stage, large-scale studies have prompted a change in the recommendation of mechanical bowel preparation combined with oral antibiotics in elective colorectal surgery. In the intraoperative stage, laparoscopic surgery has become a widespread and important component of ERAS, and more technologically advanced single-incision laparoscopic surgery and robotic surgery are the focus of active research. Ileus-prevention items, such as opioid-sparing multimodal pain management and euvolemic fluid therapy, are recommended in the postoperative stage. The adoption of ERAS protocols is expanding to encompass a wide range of surgical procedures, clinical scenarios, healthcare institutions, and professional medical societies. In order to maximize the effect by increasing adherence to ERAS, medical staff must fully understand the clinical basis and meaning of each item, and the protocol must be maintained and developed steadily through a team approach and audit system.

Citations

Citations to this article as recorded by  
  • Compliance with an enhanced recovery pathway and postoperative outcomes in elderly colorectal cancer patients: a real-world cohort and structural pathway analysis
    Liping Feng, Qingyong Huang, Songchun Liu, Shuang Wu
    Updates in Surgery.2026;[Epub]     CrossRef
  • ERAS and Gastrointestinal Site Infections: Insights from a Comprehensive Systematic Review and Meta-Analysis
    Zhiwei Wu, Xiaofang Ge, Dike Shi
    Surgical Infections.2024; 25(9): 699.     CrossRef
  • Emerging Infectious Diseases at the End of the Fourth Year of the COVID-19 Pandemic and Recent Updates on Colorectal and Pediatric Endocrine Diseases
    Sun Huh
    The Ewha Medical Journal.2023;[Epub]     CrossRef
  • 13,531 View
  • 33 Download
  • 2 Web of Science
  • 3 Crossref
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