Eosinophilic enteritis is an uncommon disease of unknown cause characterized by eosinophilic infiltration in various areas of the gastrointestinal tract with symptoms. It is generally classified according to the layer of the gastrointestinal tract involved. Eosinophilic infiltration of the serosa is the rarest form of presentation and may manifest eosinophilic ascites. We report a case of a 47-year-old man who experienced progressing abdominal pain. A diffuse erythematous change of the gastric mucosa was observed on gastrofibroscopy. An abdominal computed tomography and colonoscopy showed diffuse wall thickening of the small bowel and colon with a small amount of ascites. Eosinophilic infiltration was confirmed by multiple biopsies of the gastrointestinal tract and peritoneal fluid analysis. The patient was treated with corticosteroid and responded dramatically.

Angiolymphoid hyperplasia with eosinophilia(ALHE) is a benign, uncommon disorder of unknown etiology and usually appears as intradermal or subcutaneous, red to brown papules and/or nodules, usually located on the head and neck region, and occurring in young adults.

Histopathologically ALHE is an angiolymphoproliferative lesion which shows characteristically plump epitheloid or histioid endothelial cells, accompanied by an inflammatory infiltrate that mainly consists of lymphocytes and eosinophils.

We reported a case of angiolymphoid hypreplasia with eosinophilia occurring on the scalp in a 52-year-old female and review the literature.