Graular cell tumor is a rare benign lesion of unknown histogenensis.

A 51-year-old female had a 1.0cm sized, asymptomatic, firm nodule with erythematous, shiny, and smooth surface on her right side of posterior neck for 1 year. Excisional biopsy was done under the impression of epidermal cyst. The histologic specimen showed irregularly arranged dermal nests of large polyhedral cells containing small nuclei and coarsely granular eosinophilic granules within the pale cytoplasm. The granules were PAS-positive and diastase-resistant.

Recurrence was not found until 1 year after excisional treatment.

Granular cell tumor(GCT) is an uncommon tumor characterized clinically by an asymptomatic, solitary nodule in the tongue and skin, especially head and neck region. Histopathologically the broad fascicles of tumor cells infiltrate the dermis and the tumor cells are characterized by plump cells with faint eosinophilic, granular cytoplasm.

The origin of cells has been debated for decades. However electron microscopic and immunohistochemical studies strongly support a Schwann cell origin.

We report a case of granular cell tumor arising from the anterior chest of 12-year-old healthy girl, which exhibited the distinctive histopathologic appearance and also reactive with PAS, S-100, and NSE.